SWISS-MODEL: Bridging Sequence and Structure in Protein Science
As a pioneering platform in structural bioinformatics, SWISS-MODEL has revolutionized protein structure prediction by providing researchers with accessible tools for generating high-quality protein structure models.
Core Capabilities
- Modeling Features Structure Prediction:
- Template identification
- Sequence alignment
- Model building
- Quality assessment
- Structure refinement
- Input Options Flexible Submission:
- Single sequences
- Multiple sequences
- Structure-based modeling
- Template selection
- Custom alignment
Key Functionalities
- Automated Pipeline Process Steps:
- Template search
- Quality filtering
- Alignment generation
- Model building
- Structure validation
- Quality estimation
- Analysis Tools Built-in Features:
- Structure visualization
- Quality metrics
- Conservation analysis
- Domain annotation
- Error estimation
Research Applications
- Basic Research
- Protein function studies
- Mutation analysis
- Structure-function relationships
- Evolutionary studies
- Domain organization
- Applied Research
- Drug design
- Protein engineering
- Antibody modeling
- Disease mechanism studies
- Structure-based design
- Method Development
- Modeling algorithms
- Quality assessment
- Template selection
- Alignment methods
- Validation techniques