SWISS-MODEL

SWISS-MODEL: Bridging Sequence and Structure in Protein Science

As a pioneering platform in structural bioinformatics, SWISS-MODEL has revolutionized protein structure prediction by providing researchers with accessible tools for generating high-quality protein structure models.

Core Capabilities

1. Modeling Features Structure Prediction:

• Template identification
• Sequence alignment
• Model building
• Quality assessment
• Structure refinement

2. Input Options Flexible Submission:

• Single sequences
• Multiple sequences
• Structure-based modeling
• Template selection
• Custom alignment

Key Functionalities

1. Automated Pipeline Process Steps:

• Template search
• Quality filtering
• Alignment generation
• Model building
• Structure validation
• Quality estimation

2. Analysis Tools Built-in Features:

• Structure visualization
• Quality metrics
• Conservation analysis
• Domain annotation
• Error estimation

Research Applications

1. Basic Research

• Protein function studies
• Mutation analysis
• Structure-function relationships
• Evolutionary studies
• Domain organization

2. Applied Research

• Drug design
• Protein engineering
• Antibody modeling
• Disease mechanism studies
• Structure-based design

3. Method Development

• Modeling algorithms
• Quality assessment
• Template selection
• Alignment methods
• Validation techniques