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IntAct

IntAct is a comprehensive database of molecular interactions, providing curated molecular interaction data and tools for interaction network analysis, maintained by the European Bioinformatics Institute (EBI).

Introduction

IntAct: Understanding Molecular Interactions Through High-Quality Data

IntAct serves as a crucial resource in molecular biology by providing researchers with carefully curated molecular interaction data, enabling the study of complex biological systems and networks.

Core Components

  1. Data Content Interaction Types:
  • Protein-protein interactions
  • Protein-small molecule
  • Protein-nucleic acid
  • Genetic interactions
  • Post-translational modifications
  1. Data Quality Curation Standards:
  • Manual expert curation
  • Literature-based evidence
  • Experimental validation
  • Standardized ontologies
  • Quality control metrics

Key Features

  1. Search Capabilities Search Options:
  • Molecule identifiers
  • Gene names
  • Interaction types
  • Experimental methods
  • Publication references
  1. Analysis Tools Built-in Tools:
  • Network visualization
  • Data filtering
  • Statistical analysis
  • Export functions
  • Integration options

Research Applications

  1. Systems Biology
  • Network analysis
  • Pathway mapping
  • Interaction prediction
  • Complex identification
  • Regulatory networks
  1. Drug Discovery
  • Target identification
  • Mechanism studies
  • Drug-protein interactions
  • Side effect prediction
  • Therapeutic strategies
  1. Disease Research
  • Disease networks
  • Pathway analysis
  • Biomarker discovery
  • Mechanism understanding
  • Target validation

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