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RefSeq is NCBI's comprehensive and non-redundant database providing curated reference standards for genomic, transcript, and protein sequences across multiple species.
Understanding RefSeq's Critical Role in Molecular Biology Research
RefSeq (Reference Sequence Database) stands as one of the most fundamental resources in molecular biology, providing researchers with a stable, curated, and non-redundant set of reference sequences. This NCBI-maintained database serves as the cornerstone for genomic, transcriptomic, and proteomic research across the scientific community.
Core Functions and Features
Reference Standards The database's primary strength lies in its curation process. Each sequence undergoes rigorous validation and annotation, ensuring that researchers have access to high-quality reference materials. These sequences serve as standards for:
Data Organization RefSeq organizes its content through a sophisticated accession number system:
Quality Control and Curation The database maintains its high standards through:
Research Applications
Integration and Accessibility
RefSeq seamlessly integrates with other NCBI resources:
Tools and Features The platform provides various tools for:
Future Directions RefSeq continues to evolve with: