TCR-FramePose: a local-frame representation for decomposing global docking and CDR3 loop geometry in TCR-pMHC recognition
T cell receptor recognition of peptide-MHC depends on sequence, interface chemistry, and three-dimensional geometry, but docking geometry is often summarized at the whole-receptor level, leaving CDR3-local pose difficult to compare across structures. We introduce TCR-FramePose, a local-frame descriptor set that represents each TCR-pMHC complex as three bodies - whole TCR, CDR3a, and CDR3b - measured relative to a pMHC groove frame. For each body, FramePose decomposes the native pose into reach, offset direction on S^2, and orientation on SO(3); for tangent-space analyses, these components are mapped to six coordinates per body and 18 coordinates per complex. Applied to 378 curated abTCR-pMHC