Cancer trends in England in younger adults from 2001-2023: comparing incidence, mortality and stage at diagnosis

Objectives To compare trends in incidence and mortality rates for cancers with rising incidence in younger adults in England, and to assess whether increasing incidence is observed for early-stage, late-stage or both types of disease. Methods and analysis We used cancer incidence and mortality data from English National Disease Registration Service (2001-2023). Analyses focused on 12 cancers with increasing incidence (on average) in younger adults (20-49 years) and more than 500 cases diagnosed in 2023. Trends were quantified by estimating the average annual percentage changes (AAPCs) and 95% confidence intervals (CI) using Joinpoint regression and by calculating the excess number of cancer