Dual thalamic drive defines the intra-amygdala wiring complexity

The amygdala plays a key role in affective behaviors by integrating incoming signals and conveying them towards subcortical output regions. Current models suggest a serial information flow within the amygdala from the lateral and basolateral towards the central subnuclei driven by incoming thalamic and cortical excitation. However, due to the lack of universally accepted parcellation principles, the precise connectivity and thus, the signal propagation within the circuit remain debated. Using a molecular-based parcellation, our subnucleus-specific anatomical and electrophysiological mapping revealed a previously overlooked complexity in the intra-amygdala wiring pattern in mice. Specifically