MAP1A cleavage regulates TRIM46 transport to the axon in mature neurons

Polarised cargo transport is fundamental to neuronal function, ensuring the proper distribution of proteins and organelles between the cell body and axon. This process is tightly regulated at the proximal axon, where the enrichment of specific proteins organises the local cytoskeleton and directs intracellular trafficking. Although several microtubule-associated proteins (MAPs) have been implicated in axonal cargo transport during neuronal development, how protein localisation is maintained in mature neurons remains poorly understood. Here, we identify a previously unrecognised role for MAP1A in transporting TRIM46, a key organiser of the axonal microtubule cytoskeleton, to the axon of matur