Scalp Bacterial Microbiota Dysbiosis in Androgenetic Alopecia: Community Structure, Functional Profiles, and Associations with Lifestyle Factors

The aim of this study was to explore the scalp bacterial flora structure and functional characteristics in androgenetic alopecia (AGA) patients, analyze its association with disease phenotypes and unhealthy lifestyles, and provide a basis for clarifying AGAs microecological pathogenic mechanism and targeted interventions. A total of 7 AGA patients and 6 healthy controls (HC) were enrolled, with scalp microbial samples collected. High-throughput sequencing of the 16S rRNA V3-V4 region was used to analyze flora alpha/beta diversity, species composition and differential species. LEfSe and KEGG functional prediction screened marker bacteria and differential pathways, and clinical/lifestyle data