A reduced multicompartment network model of CA1 theta-gamma oscillations under extracellular stimulation

Deep brain stimulation has demonstrated its therapeutic potential in modulating pathological oscillations associated with Parkinson's disease and epilepsy. However, its efficacy in treating disrupted theta-gamma phase-amplitude coupling seen in memory-related disorders, such as Alzheimer's disease, remains poorly understood. While recent studies have targeted the entorhinal-hippocampal circuit, results remain inconsistent. This discrepancy stems from a lack of mechanistic understanding regarding how stimulation protocols affect this circuit. In this work, we present a reduced multicompartment model of the hippocampal CA1 area that reproduces theta-nested gamma oscillations characteristic of