Striatal lateral inhibition regulates action selection in a mouse model of levodopa-induced dyskinesia

Striatal medium spiny neurons (MSNs) integrate convergent cortical, thalamic, and dopaminergic inputs to shape motor output. In addition, MSNs form local inhibitory synaptic connections with one another. The function of this striatal lateral inhibition is unknown, but one possibility is in selecting an intended action while suppressing alternatives. The execution of selected movements is disrupted in several movement disorders, including levodopa-induced dyskinesia (LID), a complication of Parkinson disease (PD) therapy characterized by involuntary movements. Here, we identify chronic changes in the strength of striatal lateral inhibitory synapses in a mouse model of PD/LID. These synapses a