A Multiscale Computational Analysis of Myometrial Excitation during Late Pregnancy

The control of uterine activity during pregnancy is a complex process that involves regulating myometrial excitability across multiple scales. While numerous studies have investigated various regulatory mechanisms and established the contributions of ion channels and gap junctions, how these mechanisms interact to produce observed changes in uterine activity remains poorly understood. Pivotal to these efforts are computational models that effectively capture gestational changes in excitability across scales. In this study, we propose a multiscale computational modeling framework that can reproduce measured activity at the cellular and tissue scales at a given gestational stage. At the cellul