HiFiMAP: High-resolution fast identity-by-descent mapping test

Although traditional genome-wide association studies (GWAS) have identified numerous loci, they often ignore phased haplotype information. Identity-by-descent (IBD) mapping captures these extended haplotypic effects by modeling shared ancestral segments. However, standard statistical mapping of these segments scales poorly with biobank-sized cohorts and short IBD segments that capture older evolutionary events. To overcome this computational bottleneck, existing scalable IBD mapping frameworks aggregate shared segments into fixed sliding windows. While computationally efficient, this window-based approach generates association signals at a low resolution that often span hundreds of kilobases