Psychiatric polygenic profiles characterize difficult-to-treat depression versus antidepressant responders in the AGDS:Cell-o cohort

BackgroundMajor depressive disorder is highly heterogeneous, yet clinically useful subtypes remain difficult to define. Multiple studies align to suggest one-third of people respond to first line antidepressants, one-third respond after some trial-and-error, while one-third remain treatment resistant (difficult-to-treat depression, DTD). Early identification of individuals on a trajectory toward DTD is an important research goal. MethodsUsing 4.5 years of prescription records together with three self-report measures we defined seven stringently defined treatment-based groups to stratify participants of the Australian Genetics of Depression Study (AGDS). Four groups comprised antidepressant r