Corticolimbic network perturbations in clinical high-risk and first-episode psychosis: an arterial spin labelling and Ro15-4513 positron emission tomography study

Hippocampal regional cerebral blood flow (rCBF) alterations in early psychosis may result from GABAergic inhibitory dysfunction within corticolimbic circuits. Traditional rCBF and positron emission tomography (PET) analyses are regional and not typically analysed within networks of dysfunction. Here, we used a novel individualised-perturbation analysis to investigate whether corticolimbic covariance of rCBF and GABAergic receptor availability are perturbed in individuals at clinical high-risk for psychosis (CHR-P) and first-episode psychosis (FEP), and how the two may be related. Using simultaneous PET-MRI, we acquired arterial spin labelling (measuring rCBF) and [11C]Ro15-4513 PET (measurin