Mitochondrial control of glycerolipid synthesis by a PEP shuttle

SLC25A35 is revealed as the mitochondrial PEP exporter that licenses glycerolipid synthesis in lipogenic cells, linking mitochondrial energetics to lipid production. Mitochondrial PEP flux drives glycerol-3-phosphate and triglyceride synthesis, and blocking SLC25A35 reduces hepatic steatosis, offering a target for metabolic therapy.