This is IT: How accelerated intermittent theta burst stimulation relieves depression symptoms

In this issue of Cell, Gongwer et al. and Johnson et al. identify the plasticity of intratelencephalic (IT) neuronal projections to anterior insula as a central substrate mediating the antidepressant effects of accelerated intermittent theta burst stimulation. These studies suggest a revolutionary future in which brain stimulation can enable circuit-specific plasticity.