Sustaining microglial reparative function enhances stroke recovery

Nature, Published online: 13 May 2026; doi:10.1038/s41586-026-10480-0 Reparative microglia persist in the brain after stroke but become dysfunctional through ZFP384-mediated mechanisms; however, this process can be mitigated by targeting Zfp384 using therapeutic antisense oligonucleotides.