Ecotypes of triple-negative breast cancer in response to chemotherapy

Nature, Published online: 13 May 2026; doi:10.1038/s41586-026-10469-9 Treatment data for triple-negative breast cancer show the importance of macrophage subtypes and cancer-cell metaprograms for interferon signalling, HLA expression and cell cycle activity that are associated with a good response to neoadjuvant chemotherapy.