Challenges in mitigating weight regain with incretin-based therapy

Weight regain after successful weight loss is acknowledged as one of the major challenges for long-term obesity management, whatever the mode of treatment, potentially leading to a deleterious weight cycling.1 Weight regain after stopping incretin-based therapies is especially rapid and substantial, as most patients often regain roughly two-thirds of lost weight within 1 year of cessation;2 thus, different strategies should be implemented to mitigate this risk.3