研究关注：Selective DNMT1 degrader shows potent anti-leukemic activity

## 事件概览

DNA methylation, catalyzed by DNMT enzymes, is a central epigenetic mechanism frequently disrupted in cancer, where aberrant hypermethylatio...

## 核心信息

DNA methylation, catalyzed by DNMT enzymes, is a central epigenetic mechanism frequently disrupted in cancer, where aberrant hypermethylation contributes to tumor suppressor gene silencing. Researchers from Nankai University reported the discovery and preclinical characterization of [I], a selective DNMT1 degrader in models of acute myeloid leukemia (AML).

## 为什么值得关注

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