Late Onset Alzheimer’s disease risk variants in cognitive decline: The PATH Through Life Study

Recent genome wide association studies have identified a number of single nucleotide polymorphisms associated with late onset Alzheimers disease. Here we examine the associations of 24 LOAD risk loci, individually and collectively as a genetic risk score, with cognitive function. We used data from 1,626 non-demented older Australians of European ancestry who were examined up to four times over 12 years on tests assessing episodic memory, working memory, vocabulary and information processing speed. Linear mixed models were generated to examine associations between genetic factors and cognitive performance. Twelve SNPs were significantly associated with baseline cognitive performance (ABCA7, M