bioRxiv preprint

Frank-Starling law and Bowditch phenomenon may have the common theoretical grounds

The relationship between two different linear dimensions of the chamber (ventricle) and the two respective values of the force of contraction (which are applied to the imaginary piston in order to accelerate the initial venous inflow) is deduced as the ratio of forces which is equal to the ratio of squares of linear dimensions of the chamber; the equation is valid when the durations of both contractions (systoles) are identical. The relationship corresponds to Frank-Starling law (the right limb of parabola can be approximated to the direct proportionality of the law). When the durations of systoles are different the ratio of forces is equal to the inverse ratio of durations of systoles; the

Physiology
原文来源: https://doi.org/10.1101/069609