ANU-ADRI and not Genetic Risk score predicts MCI in a cohort of older adults followed for 12 years

AbstractO_ST_ABSINTRODUCTIONC_ST_ABSWe evaluated a risk score comprising lifestyle, medical and demographic factors (ANU-ADRI), and a genetic risk score (GRS) as predictors of Mild Cognitive Impairment (MCI).\n\nMETHODSANU-ADRI risk scores were computed for the baseline assessment of 2,078 participants from the PATH project. Participants were assessed for clinically diagnosed MCI/Dementia and psychometric test-based MCI (MCI-TB) at 12 years of follow-up. Multi-state models estimated the odds of transitioning from cognitively normal (CN) to MCI/Dementia and MCI-TB over 12 years according to baseline ANU-ADRI and GRS.\n\nRESULTSHigher ANU-ADRI score predicted transitioning from CN to either MC