Unlocked capacity of proteins to attack membranes characteristic of aggregation: the evil for diseases and aging from Pandora’s box

O_FIG O_LINKSMALLFIG WIDTH=200 HEIGHT=193 SRC=\"FIGDIR/small/071274_ufig1.gif\" ALT=\"Figure 1\">\nView larger version (61K):\norg.highwire.dtl.DTLVardef@3e897borg.highwire.dtl.DTLVardef@1b429f6org.highwire.dtl.DTLVardef@12f0dbeorg.highwire.dtl.DTLVardef@2f5d8f_HPS_FORMAT_FIGEXP M_FIG C_FIG AbstractAggregation of specific proteins is characteristic of a large spectrum of human diseases including all neurodegenerative diseases, while aggregation of non-specific proteins has been now identified to be a biomarker for cellular aging down to Escherichia coli. Previously, as facilitated with our discovery in 2005 that \"completely insoluble\" proteins could be all solubilized in unsalted water [So