High GC Content Causes De Novo Created Proteins to be Intrinsically Disordered

De novo creation of protein coding genes involves formation of short ORFs from noncoding regions; some of these ORFs might then become fixed in the population. De novo created proteins need to, at the bare minimum, not cause serious harm to the organism, meaning that they should for instance not cause aggregation. Therefore, although the creation of the short ORFs could be truly random, but the fixation should be of subject to some selective pressure. The selective forces acting on de novo created proteins have been elusive and contradictory results have been reported. In Drosophila they are more disordered, i.e. are enriched in polar residues, than ancient proteins, while the opposite trend