Chromatin marks govern mutation landscape of cancer at early stage of progression

Accumulation of somatic mutations over time leads to tissue abnormalities, such as cancer. Somatic mutation rates vary across the genome in a cell-type specific manner, depending on the types of mutation processes1-7. Although recent studies have identified several determinants relevant to the establishment of the cancer mutation landscape8-13, these studies have yet to propose the major time point at which these factors come into play during cancer progression. Here, we analyzed whole genome sequencing data from two different types of precancerous tissues, monoclonal B-cell lymphocytosis and Barretts esophagus, and their matching cancer types along with 423 epigenetic features from normal t