Global Reduction of Information Exchange during Anesthetic-Induced Unconsciousness

During anesthetic-induced unconsciousness (AIU), the brain undergoes a dramatic change in its capacity to exchange information between regions. However, the spatial distribution of information exchange loss/gain across the entire brain remains elusive. In the present study, we acquired and analyzed resting-state functional magnetic resonance imaging (rsfMRI) data in rats during wakefulness and graded levels of consciousness induced by incrementally increasing the concentration of isoflurane. We found that, regardless of spatial scale, the absolute functional connectivity (FC) change was significantly dependent on the FC strength at the awake state across all connections. This dependency beca